Navarro-Partida el al evaluated SNPs Asp299Gly (rs4986790 A/G) and Thr399lle (rs4986791 C/T) in Mexican patients with POAG compared to controls and found that the TLR4 coding SNPs Asp299Gly and Thr399lle was significantly higher in the POAG patients, suggesting that there is a genetic susceptibility alleles for POAG in the Mexican population54. This evidence concerns the gene TLR4 and open-angle glaucoma.