Although there was no difference in epithelial cell activity between TG and WT mice, it is possible that SPOCK1 might not affect epithelial cell proliferative activity but rather, it might diminish keratinocyte programmed death that occurs in several cancers through the activation of PI3K/AKT signaling that blocks apoptosis30,32,37,51. The gene discussed is SPOCK1; the disease is cancer.