STAT3 and central nervous system cancer: Both the glioma-infiltrating monocytes and macrophages had pro- (Arg1) and anti-inflammatory (Nos1) markers, which is in line with the global upregulation expression of IFNγ, IL10, IL4 and IL6/STAT3 cytokine pathway genes, albeit it is not clear if individual cells express both pro- and anti-inflammatory marker.