In conclusion, we have generated a novel mouse model carrying the PLN-R14del pathogenic variant, and PLN-R14Δ/Δ mice mimic human disease in a strikingly comparable but accelerated manner, whereas PLN-R14Δ/+ mice exhibit cardiomyopathy at middle age similar to human carriers (Fig. 6). The gene discussed is PLN; the disease is cardiomyopathy.