PLN-R14del carriers have a high risk of developing malignant ventricular arrhythmias (VAs) and HF, and are often diagnosed with DCM or ARVC, which, given the presence of biventricular abnormalities, is better referred to as arrhythmogenic cardiomyopathy (ACM)3,9–11. This evidence concerns the gene PLN and Arrhythmogenic right ventricular dysplasia.