Although quantification of Ki-67 and p-CDK1 levels in histological samples was limited by sample size and the extent of necrotic tissue, ki-67 levels were lower in tumor tissues of animals treated with AZD1775 plus olaparib than in animals treated with AZD1775 or olaparib and in those of vehicle controls, which indicated proliferative ability was reduced. The gene discussed is CDK1; the disease is neoplasm.