While our compiled data suggest that the lack of PINK1 and the exposure to psychological distress may adversely affect the bioenergetic status and antioxidant responses in PBMCs (Figs. 2–5), additional studies that interrogate the redox status (level of ROS species) and transmembrane potential of mitochondria in PBMCs are needed to confirm these observations. This evidence concerns the gene PINK1 and Abnormal emotional state.