PINK1 and Abnormal emotional state: Interestingly, psychological distress did not disrupt the energy metabolism in WT-PBMCs, but it enhanced the glycolytic capacity in PINK1-KO-PBMCs (p = 0.052, Fig. 3c), suggesting that long-term distress alters the mitochondrial metabolism while concomitantly enhancing glycolysis in PINK1-KO-PBMCs.