PINK1 and Abnormal emotional state: Therefore, the observation that the energy metabolism in WT-PBMCs was not affected by psychological distress suggests that depletion of PINK1 would make PBMCs highly vulnerable to oxidative stress, elicits a bioenergetic crisis, and thereby, elicits an increase in the level of antioxidant and energy production pathways, and possibly elicits downstream transcriptional activation of survival and antioxidant gene programs in a similar manner as induced by tumors63.