A factor repressed upon PRMT5 inhibition, is the Basic Leucine Zipper ATF-like Transcription Factor, BATF3 (Fig. 5b), which was shown to be required for proliferation in Hodgkin lymphoma, anaplastic large cell lymphoma as well as adult T cell leukemia/ lymphoma26,27. Here, BATF3 is linked to anaplastic large cell lymphoma.