CYP19A1 and breast carcinoma: Conversely, the modern era of systemic therapy for breast cancer includes the use of taxane-based chemotherapy regimens as well as the utilization of traztuzumab and pertuzumab for HER2 + tumors, longer (10-year) courses of tamoxifen for patients with hormone-sensitive tumors, as well as the use of aromatase inhibitors and combination therapy, all of which have likely contributed to lower recurrence rates in the current era.