An accumulation of in vitro and in vivo experimental work revealed that BBR may be beneficial to the prevention of musculoskeletal disorders, such as osteoporosis, osteoarthritis, and rheumatoid arthritis, which relied on its ability to target multiple signaling pathways including PKA, p38 MAPK, Wnt/β-catenin, AMPK, RANK/RANKL/OPG, PI3K/Akt, NFAT, NF-κB, Hedgehog, and oxidative stress signaling.12 In our study, we found that in the BBR-treated group, root repair was significantly enhanced after BBR had filled root canals for 3 weeks. This evidence concerns the gene AKT1 and rheumatoid arthritis.