In a human chondrosarcoma cell line, GABA promotes proliferation; in contrast, a GABAB-R antagonist (CGP54626) induced apoptosis by inhibition of the PI3K/AKT/mTOR and MAPK pathways and activation of caspases 3 and 9.281 These results encourage the characterization of GABAB drugs as potential co-adjuvants of current chondrosarcoma therapy. This evidence concerns the gene AKT1 and chondrosarcoma.