In fact, miR-34a knock down or antagomiR-34a is enough to transform p53WT cell-derived to p53KO cell-derived EVs, promoting neuritogenesis.225 Moreover, p53-deficient head and neck tumors are enriched with adrenergic fibers and surgical lingual (sensorial) denervation decreased tumor volume and intratumor adrenergic fibers. This evidence concerns the gene TP53 and neoplasm.