NMDAR behaves as a tumor suppressor as its agonists inhibit cancer cell proliferation by interfering with mTOR and ERK signaling pathways.271 Accordingly, multiple cancer cell lines including gastric cancer lines,273 human esophageal cancer274 and non-small-cell lung cancer cell lines275 show decreased expression of NMDAR2B subunit. The gene discussed is MTOR; the disease is neoplasm.