GDNF and Hyperglycemia: Furthermore, hyperglycemia-dependent demyelination and axonal degeneration propitiate PNI.193 Finally, PNI induces neuropathic pain during pancreatic cancer when tumor-derived factors activate sensorial fibers to trigger pain; some of the factors that increase in cancer cells are NGF, BDNF, artemin, and glial cell-derived neurotrophic factor (GDNF), while their receptors increase in nerves.187