AKR1C3 and Familial prostate cancer: The proliferative mechanism activated by GABAA-R in prostate cancer cell lines is likely mediated by transactivation of EGFR and Src-dependent proliferation.282 In fact, 3α-diol neurosteroid, synthetized from 5α-dihydrotestosterone by AKR1C3 (Aldo-keto reductase family 1 member C3), induces PC-3 cell proliferation and promoted growth of large vascularized tumors in a GABAA-R-dependent manner.