Therefore, β2-adrenergic antagonists (ICI-118, 551, propranolol, but not atenolol) and inhibitors of Trk receptors (pan-Trk inhibitor PLX-7486), potentiate the therapeutic effect of gemcitabine, prolonging mice survival, and non-selective β-blocker treatment prolong survival of patients with PDAC.185 Interestingly, hyperglycemia increases cancer cell proliferation and induces NGF overexpression, promoting PNI in pancreatic cancer. Here, NGF is linked to cancer.