The knocking down of MAP2 decreased the generation of neurons from human gastric and colorectal cancer stem cells and reduced the growth of tumor xenografts derived from human colorectal cancer stem cells.235 Similarly, as characterized in glioblastoma, tumor stem cells differentiate to endothelial-like cells forming vessels that irrigate tumors.237,238 Destroying cancer stem cells, as well as pharmacological inhibition of cancer stem cell differentiation, could prevent cancer progression. This evidence concerns the gene MAP2 and colorectal cancer.