Besides, interactions between vitamin D and Wnt/β-catenin pathway has also been reported in different cellular contexts such as colon cancer cells [117], in which 1,25(OH)2D3 acts upregulating the extracellular Wnt inhibitor DKK1 antagonizing of Wnt/β-catenin pathway [118], promoting VDR/β-catenin interactions [119], thus reducing the β-catenin-dependent gene expression or facilitating the sequestration of β-catenin by E-cadherin at plasma membrane adherents junction [117, 119, 120]. The gene discussed is VDR; the disease is malignant colon neoplasm.