MAPK8 and non-small cell lung carcinoma: To test whether Wnt7a overexpression and irradiation inhibited the proliferation and induced the apoptosis in NSCLC cells through the JNK or β-catenin pathways, we examined the phosphorylation levels of JNK (Thr183/Tyr185) and β-catenin (Thr-41/Ser-45, Ser-552, Ser-675 and Ser-45) by western blot (Fig. 3).