To further elucidate whether Wnt7a overexpression sensitized irradiation was associated with the mitochondria-dependent apoptotic pathway in NSCLC cell lines, we examined the expression of caspase-3, caspase-7, caspase-9, PARP, Bcl-2, Bax and cytochrome c induced by the combination of Wnt7a overexpression and irradiation (Fig. 5). This evidence concerns the gene CASP7 and non-small cell lung carcinoma.