Our results indicated that the combination of Wnt7a overexpression and irradiation decreased the Bcl-2 expression, increased the activation of Bax, caused the release of cytochrome c, and enhanced the activation of caspase-3, caspase-7 and caspase-9 in NSCLC cells (Fig. 5). Here, WNT7A is linked to non-small cell lung carcinoma.