The resulting relative sensitivities indicated that the efficiency of cytotoxic T cells at killing cancer cells (parameter 14), as well as kinetic parameters related to the proliferation rate of the cancer cells and the CD8+ cytotoxic T cells (parameters 4, 5, and 8), had the highest sensitivities and thus the largest effect on the strength of the response to treatment (Figures 6A and 6B). This evidence concerns the gene CD8A and cancer.