Linking DBP with type 2 diabetes (T2D) risk, GC variants are associated with elevations in fasting glucose, fasting insulin levels, and impaired responses to oral glucose challenge (Baier et al., 1998, Hirai et al., 2000, Iyengar et al., 1989, Szathmary, 1987). Here, INS is linked to type 2 diabetes mellitus.