For the ensuing studies we narrowed our analyses to MEIS1 due to the 72.12% sequence similarity shared by MEIS1 and MEIS2, the phenocopied growth suppression in vitro and in vivo (Figure 1; Figure 1—figure supplement 1D and E), the complexity of experimental design around multiple MEIS2 isoforms, and their similarly reduced expression in prostate tumors and cancer cells (Bhanvadia et al., 2018). This evidence concerns the gene MEIS2 and cancer.