DCN and neoplasm: DCN belongs to the small-leucine-rich-proteoglycan (SLRP) family of proteins that has been well-documented to decrease tumor growth and progression (Bi and Yang, 2013; Csordás et al., 2000; Edwards, 2012; Goldoni et al., 2009; Hildebrand et al., 1994; Iozzo et al., 1999; Järvinen and Prince, 2015; Khan et al., 2011; Santra et al., 2002; Schönherr et al., 1998; Schönherr et al., 2005; Zhang et al., 2018; Zhu et al., 2005).