Moreover, we previously demonstrated that dual MEIS1/MEIS2 knockdown in LAPC4 cells increased tumor xenograft growth Bhanvadia et al., 2018; analysis of DCN protein in these cells showed decreased DCN expression when MEIS1, MEIS2, and both MEIS1 and MEIS2 were depleted using shRNAs (Figure 5—figure supplement 2A). This evidence concerns the gene MEIS2 and neoplasm.