LUM and neoplasm: Lumican (LUM), which also increased with LV-MEIS1 expression (fold-change = 2.88, FDR = 1.79×10−9), is another member of the tumor-suppressive SLRP protein family and has been shown to increase integrin B1 (ITGB1)-mediated adhesion as well as regulate expression of ITGB1 (D'Onofrio et al., 2008; Jeanne et al., 2017; Zeltz et al., 2010).