MEIS2 and prostate neoplasm: For the ensuing studies we narrowed our analyses to MEIS1 due to the 72.12% sequence similarity shared by MEIS1 and MEIS2, the phenocopied growth suppression in vitro and in vivo (Figure 1; Figure 1—figure supplement 1D and E), the complexity of experimental design around multiple MEIS2 isoforms, and their similarly reduced expression in prostate tumors and cancer cells (Bhanvadia et al., 2018).