As a cell transforms to a malignant state, MEIS1/2 are epigenetically silenced in more aggressive prostate tumors (Bhanvadia et al., 2018) and expression of tumor-suppressive proteoglycans is suppressed, leading to decreased regulation of oncogenic signaling through pathways such as TGFβ, EGFR, cMYC, WNT, and IGF1R (Figure 7C). This evidence concerns the gene IGF1R and neoplasm.