BIN1 and Alzheimer disease: Interestingly, our analysis has uncovered that two other AD risk factors were highly associated with RIN3; BIN1 (bridging integrator 1) (PSMs = 22, coverage = 38% and detected peptides = 15) and CD2AP (CD2-associated protein) (PSMs = 21, coverage = 30% and detected peptides = 17) (Supplementary Table 1).