RIN3 and Alzheimer disease: Furthermore, in a 2017 study of gene methylation profiling of blood and brain samples from 22 AD and 26 normal control subjects (27 males, 21 females), AD samples showed significant group-wide hypomethylation of 7 CpGs located within the 3’UTR of RIN3 (CpG1 p  =  0.019, CpG2 p  =  0.018, CpG3 p  =  0.012, CpG4 p  =  0.009, CpG5 p  =  0.002, CpG6 p  =  0.018, and CpG7 p  =  0.013, respectively) [24].