APOE and early-onset autosomal dominant Alzheimer disease: Following the initial discovery of RIN3 association with LOAD in a large scaled GWAS in 2011 [13], genetic variant RIN3 was identified in a prospective cohort study of 74,754 individuals together with BIN1 and CD2AP to be associated with increased risk of Alzheimer’s disease, all dementia, and suggested vascular dementia independent of the strong APOE ε4 allele [54].