The expression of p-JNK was actually increased in SUP-B15 cells and four patient-derived Ph+ B-ALL cells after the dasatinib treatment (Supplementary Fig. S1a, b, c, d, e and f), indicating that JNK may be the key signaling for dasatinib resistance in Ph+ B-ALL. This evidence concerns the gene MAPK8 and acute lymphoblastic leukemia.