To investigate whether any of the three most promising biomarkers, namely Coro1A, Isg15 and Arhgdib, identified and validated in SLE mouse models appear in human sera, an MRM-MS analysis was performed using sera from 16 SLE patients with established nephritis, 18 SLE patients without nephritis and 24 aged- and sex-matched healthy controls. This evidence concerns the gene ISG15 and systemic lupus erythematosus.