Results have indicated that the mean level of β2M in the serum of the leukoplakia, oral submucous fibrosis, OSCC patients and in the control group was 2597 ± 148.6, 2187.68 ± 678.6, 3166.04 ± 357.7, and 1542.60 ± 377.70 ng/mL, respectively. This evidence concerns the gene B2M and oral submucous fibrosis.