TAP1 and colorectal cancer: The 4-fold and 2-fold increases at 48 h and at day 15 (respectively) for TAP1 demonstrate reovirus’ protective effect, as TAP1 encodes a protein critical for the expression of peptides on the surface of MHC Class I, and down-regulation of this protein has been shown to promote immune evasion and poor prognosis in colorectal cancer [19].