KRAS and colorectal carcinoma: Reovirus (a naturally occurring, ubiquitous double stranded (ds) RNA virus) has been shown to preferentially replicate in and be cytopathic to transformed cells possessing an activated KRAS-signaling pathway [7], demonstrate in vivo activity in CRC cell-line models [8], and have synergistic activity with irinotecan in KRAS-mutated CRC cell lines and xenograft models [9–11].