As shown in the present study, laparoscopic-based perivascular RDN successfully destroys sympathetic nerve fascicles and prevents the increasing trends in SBP, DBP, renal NE levels and TH expression in the renal arteries of Bama minipigs fed a high-fat diet, indicating that laparoscopic-based perivascular RDN prevents the occurrence and development of hypertension and may be an alternative strategy for controlling blood pressure. The gene discussed is TH; the disease is Hypertension.