RNF123 and neoplasm: Conversely, in the invasive lesions of the tumor sections of KPC1 mice, the CK19+ ductal differentiation pattern was abolished, AATK expression was silenced, CK19 polarity became disoriented, and HNF1A was ectopically expressed in the nucleus of cells but they lacked acinar morphology, clustered acinar architecture, or ductal epithelium continuity (Fig. 7a, KPC1).