Dramatic increases in differentiation markers CD11b and CD14 (Fig. 2d, e) and prominently lobulated karyotypes were observed in GFP+ cell population from sh-LAMP5-AS1-transfected mice (Fig. 2f), implying that LAMP5-AS1 is necessary to inhibit differentiation in MLL leukemia cells. Here, LAMP5 is linked to leukemia.