KMT2A and leukemia: We further analyzed H3K79me2 and H3K79me3 profiles by chromatin immunoprecipitation and found that 1560 genes display loss of both H3K79me2 and H3K79me3 marks compared to sh-NC data (Fig. 5c), indicating that LAMP5-AS1 participates in the regulation of genomic or sectional H3K79me2/3 modifications in MLL leukemia.