Notably, LAMP5-AS1 knockdown produced dramatic decrease in H3K79me2 and H3K79me3 levels both in the MOLM13 cells as well as in the primary MLL leukemia cells, as assessed by western blotting (Fig. 5a, b), suggesting that LAMP5-AS1 could be a critical factor for higher H3K79-methylated states. Here, PTGDR is linked to leukemia.