The results showed that the expression levels of MLL fusion protein target genes in leukemia, including the key stemness genes in HOXA cluster and MEIS1 [46], were significantly decreased in both primary MLL leukemia cells and MLL cell lines upon LAMP5-AS1 knockdown compared to cells with control treatment (Fig. 5h, i; Additional file 1: Figure S6a-c). Here, KMT2A is linked to leukemia.