These factors include age at treatment, performance status (either Karnofsky performance score [KPS] or Eastern Cooperative Oncology Group-performance score [ECOG]), visceral metastasis, other bone metastasis, ambulatory status, PSA, time from the primary PCa diagnosis, spinal tumor location, Gleason grade, lymph metastasis, number of involved vertebrae, hormone status, BP treatment and the time developing motor deficit. The gene discussed is KLK3; the disease is bone metastasis.