As CD54 (also known as intercellular adhesion molecule 1, ICAM-1) promotes DC-T cell binding, this indicates possible negative effects on the capacity of DCs to activate T cells in order to induce an adaptive immune response in GI tumours with lower levels of IL-2 and higher levels of Ang-2 and bFGF. The gene discussed is IL2; the disease is digestive system neoplasm.