A specific endometrial cancer organoid line was most sensitive to everolimus (an inhibitor of mammalian target of rapamycin [mTOR]), which suggested a strong dependence on the PI3K-AKT pathway and was in line with mutations in the pathway’s signaling mediators (PTEN, PIK3CA, AKT1) [24]. The gene discussed is PIK3CA; the disease is endometrial cancer.