Subsequently, to identify the reason for low METTL14 in CRC, we analyzed the ChIP-Seq results from ENCODE database, we focused on H3K4me3 and proved that KDM5C-mediated demethylation of H3K4me3 inhibited METTL14 transcription and lead to the suppression of METTL14 in CRC through ChIP and western blot assays. Here, KDM5C is linked to colorectal carcinoma.