METTL14 and colorectal carcinoma: To uncover the mechanism of low METTL14 expression in CRC, we analyze the ChIP-Seq data of H3K4me3 in the Encyclopedia of DNA Elements (ENCODE) database, and found that the enrichment of H3K4me3 in the promoter region was markedly lower in CRC cells than that in normal colorectal tissues (Fig. 2a).