Using UALCAN database (http://ualcan.path.uab.edu/analysis.html), we found that KDM5C mRNA expression was markedly upregulated in CRC tissues (Additional file 3: Fig. S1a), in agreement with the results from TCGA database, KDM5C mRNA expression levels was elevated in our CRC cohort (Additional file 3: Fig. S1b), and the expression of METTL14 was negatively correlated with the KDM5C expression levels (Additional file 3: Fig. S1c). The gene discussed is METTL14; the disease is colorectal carcinoma.