Furthermore, we assessed the physiological relevance of METTL14 to CRC metastasis in vivo, stable cells with modified METTL14 expression were tail-vein injected into the BABL/c nude mice, after 8 weeks, HCT116 cells with METTL14 deficiency dramatically facilitated CRC cell metastasis (Fig. 3e), as evidenced by the number of lung metastatic lesions, in contrast, overexpression of METTL14 markedly inhibited CRC cell metastasis, as shown by the number of lung metastatic lesions (Fig. 3f). This evidence concerns the gene METTL14 and colorectal carcinoma.