Here, we also show that CH25H is upregulated in AD brain tissue compared to age-matched controls as well as in three mouse models of AD pathology; APP/PS1 transgenic mice, tau transgenic mice (PS19) and a recently described APOE4xP301S (TE4) tau transgenic mouse model of accelerated tau pathology and neurodegeneration [43]. The gene discussed is PSEN1; the disease is Alzheimer disease.