CH25H and X-linked adrenoleukodystrophy: CH25H deficient mice have also been shown to have decreased inflammatory-mediated pathology and death following influenza infection [80], reduced immune responses both following experimental autoimmune encephalomyelitis (EAE) [81] and in a mouse model of X-linked adrenoleukodystrophy (X-ALD) [82], again supporting a pro-inflammatory and potentially “toxic” function of 25-HC in inflammatory and neurodegenerative disorders.