Finally, it is important to underscore that CH25H has been shown to be upregulated in a specific subset of microglial genes associated with neurodegeneration, called disease-associated microglia (DAM), in several neurodegenerative disease models (see Supplementary Fig. 2a) based on the public database published by Friedman et al. 2018 [92]. Here, CH25H is linked to neurodegenerative disease.