One of the more important relevant evidence documented in this study is the association of Non-IDA with zinc levels, namely zinc deficiency associated with increasing IDA and zinc overload having a protective effect, In one hand, during zinc deficiency, the withdraw of zinc from tissues may occur, leading to increased hepcidin synthesis, which will reduce iron uptake, affecting erythropoiesis, even in the presence of adequate iron stores [61, 62]. This evidence concerns the gene HAMP and Zinc deficiency.