In a recent high throughput functional screening study for all possible DNA binding mutations in TP53, p. A138V hotspot mutation at TP53 was found to have similar functional score (RFS > 0) as the well known TP53 cancer hotspot positions (p.R175H, p.G245S, p.R248Q, p.R249S, p.R273H and p.R282W) (Kotler et al. 2018). Here, TP53 is linked to cancer.