ERBB2 and breast cancer: The ERBB2/Her2-neu -targeted therapies, such as trastuzumab, lapatinib and pertuzumab, have showed improved outcomes in patients with ERBB2/Her2-neu amplification-positive cancers, and these drugs have been approved by the FDA against ERBB2/Her2-neu-positive gastric and breast cancers (Ying et al. 2016).