For example, Tang et al. discovered an indirect effect, suggesting that HMGB1 stimulates the production of IL-23 in mouse melanoma in a RAGE-dependent manner, IL-23 promotes the expression of IL-17 produced mainly by γδT cells, and increased IL-17 levels can promote MDSC aggregation and tumor angiogenesis in mouse tumor tissue [57]. This evidence concerns the gene IL17A and melanoma.