TGFB1 and neoplasm: On the one hand, MDSCs can produce high levels of immunosuppressive molecules, such as arginase 1 (ARG1), iNOS, TGFβ, IL-10, COX2, and indoleamine 2,3-dioxygenase (IDO), to immediately inhibit effector T cell-mediated cytotoxicity to tumor cells.