Therefore, in the present study, we associated FoxM1 with miR-320 in human GCA tissues, GCA cell lines and GCA-tumor-bearing mice, and found a negative correlation between miR-320d expression and FoxM1 expression, that is down-regulation of miR-320d could lead to increase FoxM1 expression both in mRNA level and protein level, which promote tumor progression and resulting in poor clinical prognosis. The gene discussed is FOXM1; the disease is neoplasm.