FBXW7 is a vital tumor suppressor and commonly deregulated ubiquitin-proteasome system protein in human cancer 57, which affects the tumor microenvironment and inhibits tumor metastasis by augmenting the activation of chemokine CCL2 expression, which recruits monocytic myeloid-derived suppressor cells and macrophages to the tumor site 58. Here, CCL2 is linked to neoplasm.