Glioma cells secrete EVs containing proteins (EGFR/EGFRvIII, MGMT and APNG) and RNAs (miR-21, miR-23, miR-29a, miR-30a, miR-221 and miR-451) to regulate the proliferation of recipient cells via several signaling pathways (AMPK, AKT, and MAPK) 54-57. Here, AKT1 is linked to central nervous system cancer.