Due to replication of donor cell membrane composition and function related with tumor tropism dependent on CCL2/CCR2 chemokine axis, MiV loaded with Dox are able to specifically recognize and interact with tumor cells and bypass phagocytic clearance, and then utilize the mechanism of SNARE-mediated membrane fusion to facilitate direct drug transport to nucleus rather than endocytic degradation. This evidence concerns the gene CCR2 and neoplasm.