We further studied the mechanism of circHIPK3 on promoting RC, and found that it is closely related to the promotion of carcinoma cell proliferation and EMT, the down-regulation of the expressions of C caspase-3, Bax and E-Cad, and the up-regulation of the expressions of Bcl-2, N-Cad, Vimentin, and Ki-67. The gene discussed is CDH2; the disease is carcinoma.