As the depiction of Fig. 4e, the repression of circ_0000284 expression resulted in the conspicuous lessening of ki67, Fibronectin and MMP9, and promotion of E-cadherin, insinuating that sh-circ_0000284 inhibited the proliferation and metastasis of NSCLC cells. Here, CDH1 is linked to non-small cell lung carcinoma.