In addition to the potential development of muscle-intrinsic mitochondrial dysfunction, a systemic consequence of dysregulated PPARG is the development of insulin resistance (IR)24, which is commonly associated with type 2 diabetes, obesity, and metabolic syndrome, and appears to have a bidirectional relationship with BC, with individuals with IR at greater risk of BC and BC survivors at an increased risk of IR25,26. This evidence concerns the gene PPARG and Insulin resistance.