WWTR1 and cancer: Importantly, YAP/TAZ could respond to a complex physical microenvironment and mechanical cues, ranging from ECM properties, cell geometry, cell density, and cell polarity to shear stress.188 The overall consequences of YAP/TAZ activity during cellular mechanobiology include organogenesis, tissue homeostasis and multiple diseases, such as fibrosis, pulmonary hypertension, inflammation, muscular dystrophy, and cancer.188,189