A stepwise regression analysis was performed to determine the possible influence of group, medications (beta-blockers, angiotensin-converting enzyme inhibitors, diuretics, hypoglycemic, lipid-lowering, and antiplatelet/anticoagulant), and risk factors (past of smoking, hypertension, dyslipidemia, and diabetes) on the main studied variables (HR, VO2, number of participants with EFL, degree of EFL, ERV, and IRV). The gene discussed is ACE; the disease is metabolic syndrome.