Given that autophagy stimulation has been proposed to combat proteinopathy in neurodegeneration42, we assessed the effect of LRRK2 kinase inhibition on LC3B conversion in G2019S-LRRK2 cells as a possible biological substrate underlying the reduction of pS129-aSyn inclusions (Fig. 4d–f). Here, MAP1LC3B is linked to proteostasis deficiencies.