Moreover, we identified miR-674-5p as a key miRNA that was markedly induced in endotoxemia-induced intestinal injury and was found to target X-box binding protein 1 (XBP-1), which in turn, inhibited intestinal crypt cell proliferation and exacerbated intestinal injury during endotoxemia. The gene discussed is XBP1; the disease is serum lipopolysaccharide activity.