The low metastatic potential breast cells such as MCF7 and SUM159 all showed high-expression of LIFR, which involving in bone metastases 52,53, and both PAK4 and RUNX1 regulate the expression of LIFR10,54, suggest that PAK4 and RUNX1 may be involved in regulating the metastasis of breast cancer cells with low metastatic potential. The gene discussed is PAK4; the disease is breast cancer.