Recent studies have revealed that LILRB2 blockade polarized tumor-infiltrating myeloid cells from non-small cell lung carcinoma (NSCLC) tumor tissues toward an inflammatory phenotype, and can potentially act as a myeloid immune checkpoint by reprogramming tumor-associated myeloid cells and provoking antitumor immunity 44. This evidence concerns the gene LILRB2 and non-small cell lung carcinoma.