In conclusion, SETDB2 interacts with ΔNp63α, methylates and stabilizes ΔNp63α to upregulate the transcription of the Hedgehog signaling pathway-associated genes CXCR4, PTCH1 and GLI2, which promote breast cancer stem cell maintenance and tumor initiation (Figure 7). Here, CXCR4 is linked to neoplasm.