In conclusion, SETDB2 interacts with ΔNp63α, methylates and stabilizes ΔNp63α to upregulate the transcription of the Hedgehog signaling pathway-associated genes CXCR4, PTCH1 and GLI2, which promote breast cancer stem cell maintenance and tumor initiation (Figure 7). The gene discussed is GLI2; the disease is breast carcinoma.