Third, a few researchers discovered a circRNA/miR1/mRNA1 axis and circRNA/miR2/mRNA2 axis that functioned synergistically, such as Circ-SHKBP1, which was found to affect glioma-exposed endothelial cells via miR-544a/FOXP1 and miR-379/FOXP2 axes 18. The gene discussed is SHKBP1; the disease is central nervous system cancer.