In the tumorigenesis, CtBPs function as corepressors and they can cooperate with transcription factors to repress the expression of tumor suppressors such as Bax (BCL2 Associated X protein), Bim (also known as BCL2L11, BCL2 Like 11), BRCA1 (Breast Cancer Type 1), and CDH1 (Cadherin 1) 37. This evidence concerns the gene BCL2L11 and neoplasm.