Mechanistically, lnc-EGFR binds specifically to EGFR, inhibits its ubiquitination and subsequent degradation, and sustains the activation of its downstream AP-1 and NF-AT1, two transcription factors for FOXP3, therefore leading to the enhancement of Tregs immunosuppressive function and promotion of HCC progression 27. Here, NFATC2 is linked to hepatocellular carcinoma.