Interestingly, according to the data from GEPIA (http://gepia.cancer-pku.cn/index.html) 27 and the analysis from TCGA database, mRNA levels of RNF8 and MYC were positively correlated with each other in colon cancer tissues but not in normal tissues (Figure 1C and 1D, Table S1), indicating that RNF8 might have a specific relationship with MYC in colon cancer. Here, MYC is linked to malignant colon neoplasm.