Cox regression analysis revealed that colon cancer patients with high RNF8 expression had a 2.101-fold increased risk of death compared with patients with low RNF8 expression (HR=2.101, 95% CI=1.210-3.648, p=0.008), and patients with high c-Myc expression had a 1.769-fold increased risk of death compared with low c-Myc expression (HR=1.769, 95% CI=1.015-3.082, p=0.044) (Table S3), suggesting a potential relationship of RNF8 with c-Myc in the poor prognosis of colon cancer patients. Here, RNF8 is linked to malignant colon neoplasm.