FBP1 is widely reported to be downregulated, due to abnormal methylation of its promoter sequence in non-small cell lung cancer (NSCLC) 96, HCC 97, basal-like breast tumor 98, gastric cancer 99, small intestinal neuroendocrine tumor 100 and colon cancer 101. The gene discussed is FBP1; the disease is non-small cell lung carcinoma.